Scientists from Cleveland, Ohio, and Paris, France, reached an important milestone in understanding a molecular cause of a rare, but serious birth defect, Holoprosencephaly. In this February's FASEB Journal, researchers explain why and how some fetal brains fail to develop two lobes, as well as why and how the related skull and facial defects occur. Information from this study will enable researchers to pursue better approaches toward detecting, preventing, and treating this serious disorder.Source: Federation of American Societies for Experimental Biology

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The finding is in the current issue of Annals of Neurology, a leading international neurology journal, in work led by Professor Nigel Laing and Dr Kristen Nowak of the Laboratory for Molecular Genetics at the Western Australian Institute for Medical Research (WAIMR) and done in collaboration with a number of European researchers.

Source: Research Australia

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Source: Washington University School of Medicine

By all expectations, it shouldn't have worked as well as it did. A combination of bone marrow transplantation and gene therapy greatly lengthened the lives of laboratory mice doomed by a rapidly progressing, fatal neurodegenerative disorder also found in people.

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